For 1 in 6 couples who need help to start a family, male factors will be the cause of up to 30% of infertility problems. Although a general sperm analysis remains the "golden rule" for assessing sperm quality (controls of factors such as volume, number, motility, morphology, etc.), the 25 - 40% of male infertility cases could remain "unexplained" after sperm analysis.
One factor that could cause this "unexplained" infertility is oxidative stress. High levels of oxidative stress have been linked to poor sperm function and cell damage to DNA, potentially increasing the risk of failed IVF results. But what is oxidative stress and how does it affect male fertility?
What is oxidative stress?
The oxygen that enters our body through respiration is utilized at a rate of 95% for energy production, while the remaining 5% is used for the production of free radicals.
Free radicals in small quantities are essential for our immune system, and when their concentration rises above normal, they can cause a variety of problems, such as damage to tissues, cell membranes and cell DNA, including sperm. This is called oxidative stress.
Oxidative stress and male fertility
High levels of oxidative stress have been linked to poor sperm function, abnormal sperm analysis results and failed IVF results. There is evidence that high levels of oxidative stress can cause changes in sperm membranes, affecting their morphology and motility, as well as damaging their DNA. This DNA damage could lead to lower pregnancy rates and a higher risk of miscarriage.
What causes oxidative stress?
Our ability to produce antioxidants is controlled by our genetic makeup and can be influenced by the lifestyle and diet we follow. Free radical production is increased by many factors, such as smoking, alcohol and poor quality diet high in saturated fats, as well as aging and overweight. The production of antioxidants in our body should be sufficient to balance the production of free radicals, but for many people there may be more free radicals, leading to cell damage and long-term health effects.
Dealing with high levels of oxidative stress
As sperm is created every day, you can improve the quality of your sperm in just three months with simple lifestyle changes.
The important thing to remember is that once we have a diagnosis of sperm oxidative stress (or any other male infertility problem), there are many things we can do to give you the best chance of conceiving.
* The content on this blog is not intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of qualified health care providers with questions you may have about medical conditions.